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More Swine H3N2v Match Failures

Discussion in 'Queens Park Rangers' started by kiwiqpr, Feb 10, 2012.

  1. kiwiqpr

    kiwiqpr Barnsie Mod

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    More Swine H3N2v Match Failures
    Recombinomics Commentary 23:15
    February 9, 2012

    The USDA released series of swine sequences from 24 isolates (6 H1N1, 15 H1N2v, 3 H3N2v). 23/24 were from 2011, including two H3N2v isolates from samples collected November 15, 2011 (see list here). The sequences included M gene sequences from 11 isolates, including the three H3N2v. Four of the M genes were from H1N1pdm09, but all four were from H1N2v isolates. Thus, none of the 24 isolates matched the twelve 2011 human H3N2 cases. However, this series followed a release of H3n2v sequences last week which included three with an H1N1pdm09 gene and one, A/swine/Iowa/A01202640/2011, matched the human cases.

    Two of the H1N2v isolates released today matched the H1N2 parental isolate from Ohio, A/swine/Ohio/FAH10-1/2010 ,which is the most common swine H1N2 sequence. However, even though this constellation has an H1N2M gene and an N2 and PB1 which matches the human cases, no matching H1N2v human case has been identified. The only H1N2v human case since the 2009 pandemic is an isolate with a swine M gene. Similarly, the H3N2v sequence released last week increased the number of isolates with an H1N1pdm09 M gene, but that constellation, which also has H1N1pdm09 NP and NS genes also has not been identified in humans.

    These swine sequences have been from isolates identified under enhanced surveillance, yet only two swine isolates (A/swine/NY/A01104005//2011 and A/swine/Iowa/A01202640/2011) matching the 12 human 2011 H3N2v cases have been identified, and both were from September isolates, which followed the initial human cases in July and August.

    Thus, the latest series of sequences released last week and today suggests that no matching sequences will be found in samples collected prior to the initial human cases, and the number of 2011 isolates will be limited, adding further support for the transmission of H3N2v in humans.
    Neither of the matching swine isolates have been linked to human cases, and the five most recent confirmed cases were from clusters in Iowa and West Virginia which had no swine exposure. The West Virginia index case was linked to 23 contacts with influenza like illness, and the sequences from the one tested case matched the index case.

    Although the CDC issued an alert, no additional cases have been identified. The detection is dependent on cross reactivity with seasonal H3N2 or H1N1pdmo MP genes, and most of the prior cases tested negative, inconclusive, or as seasonal H3N2, so detection of additional cases after seasonal H3N2 and H1N1pdm09 levels increase is limited.

    Media Link
     
    #1
  2. rangercol

    rangercol Well-Known Member

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    What the ****?!!
     
    #2
  3. Dave Thomas

    Dave Thomas Active Member

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    Told you I was ill
     
    #3
  4. kiwiqpr

    kiwiqpr Barnsie Mod

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    when i saw the headline i thought it could be about matchfixing

    having read the first paragraph though it might not be

    then again it could be
     
    #4
  5. Sooperhoop

    Sooperhoop Well-Known Member

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    Have they been checking Joey Barton's DNA again?...:grin:
     
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  6. Dave Thomas

    Dave Thomas Active Member

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    Om
    asatoma sadgamaya
    tamasoma jyothirgamaya
    mrithyorma amrutangamaya
    om shanti, shanti, shanti
     
    #6
  7. kiwiqpr

    kiwiqpr Barnsie Mod

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    the telepathy must be working
     
    #7
  8. Sooperhoop

    Sooperhoop Well-Known Member

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    A touch of the old Buddha's DT?...:grin:
     
    #8
  9. Sooperhoop

    Sooperhoop Well-Known Member

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    I've got it now! It's the Sri Lankan football team, they're playing a 2-2-2-4 formation...<laugh>
     
    #9
  10. Queenslander!!

    Queenslander!! Well-Known Member

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    Either that or the Coke and E's mix.....
     
    #10

  11. kiwiqpr

    kiwiqpr Barnsie Mod

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    i think its the name of their coach
     
    #11
  12. Queenslander!!

    Queenslander!! Well-Known Member

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    I'm more worried as to whether he cut and pasted that, or sat there and typed the whole thing in....?

    Concerned.com
     
    #12
  13. kiwiqpr

    kiwiqpr Barnsie Mod

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    assuming 1 pound a letter this would be 84 quid plus the shirt cost
     
    #13
  14. WBA2_QPR3

    WBA2_QPR3 Well-Known Member

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    Christ I've got to stop drinking on a Thursday night, I must be on some medical research forum
     
    #14
  15. kiwiqpr

    kiwiqpr Barnsie Mod

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    did you sign the waiver
     
    #15
  16. Sooperhoop

    Sooperhoop Well-Known Member

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    I think this one is a nomination for the monthly award 'Nuttiest thread of the month'...
     
    #16
  17. Dave Thomas

    Dave Thomas Active Member

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    ****** ***** death by buonje ***** karma ***** ghostbusters
     
    #17
  18. Dave Thomas

    Dave Thomas Active Member

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    please log in to view this image


    I think my toenails need cutting
     
    #18
  19. Azmi

    Azmi Well-Known Member

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    Looks like the game against Wolves finally tipped some of us over the edge!
     
    #19
  20. WBA2_QPR3

    WBA2_QPR3 Well-Known Member

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    Is it wrong?

    As a displaced West Londoner now living up North I must admit that I've been wearing thermal underwear since last September. I fear I am becoming addicted to this and I seem to be conditioned to leaving the heated seat on in the car all year round? Is this the first sign of the Male Menopause? DT surely you've been through this?
     
    #20

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