Off Topic Covid 19 restrictions have done one

Pangalos was referred to, by the very senior Scientists, as LGC. After coming out of a meeting with some of them I had to ask who & what was LGC. I was seriously shocked by the meaning.

My dealings with him are that he’s a Little **** with Greek heritage.

 

I haven't heard an update today but yesterday's briefing with Dr Death, or something I heard on the news, said the Oxford vaccine had been mainly trialled on young people - they had no data at that time on the effectiveness on older people. Thanks a lot for that!

 

From the guardian 5 days ago.

Phase 2 trial data shows strong immune response in over-70s and better ...

https://www.theguardian.com/world/2...ne-could-build-immunity-in-older-people-study

 

https://www.hulldailymail.co.uk/news/hull-east-yorkshire-news/come-dine-with-me-lockdown-4725571

145 comments and counting

 

And how many times have they been strung up?

 

You'd need a very sturdy rope for some of em

 

608 Deaths today. Highest since May.

Boris’s side kick reckons it will all be over come Easter.

More good news eh...

 

Just had a look on Hull Live and I see that Freddie Starr has died again!

 

Freddie is 32.4% of the Covid deaths, and the hamster is 17.4%

 

The other 58.7% had a positive covid test within the last 28 days.

 

Big reduction though

 

Top of the league my left gonad. Stand on some streets in Hull, take just one step forward and you're among hundreds of houses in Cottingham, Bilton, Hessle et al, bogus figures.

 

This has us dropping to second.

 

UK leaders have agreed 3 households can meet over the festive period.


What that means is that they knew people would go and see their family anyway so they’re pretending they’re still in control of setting the rules.

 

Exactly....the veneer/illusion of control and authority when all they are permitting what people were going to do anyway! Right or wrong.

 

Oxford vaccine: How did they make it so quickly? - BBC News

Ten years' vaccine work achieved in about 10 months. Yet no corners cut in designing, testing and manufacturing.

They are two statements that sound like a contradiction, and have led some to ask how we can be sure the Oxford vaccine - which has published its first results showing it is highly effective at stopping Covid-19 - is safe when it has been made so fast.

So, this is the real story of how the Oxford vaccine happened so quickly.

It is one that relies on good fortune as well as scientific brilliance; has origins in both a deadly Ebola outbreak and a chimpanzee's runny nose; and sees the researchers go from having no money in the bank to chartering private planes.

The work started years ago

The biggest misconception is the work on the vaccine started when the pandemic began.

The world's biggest Ebola outbreak in 2014-2016 was a catastrophe. The response was too slow and 11,000 people died.

"The world should have done better," Prof Sarah Gilbert, the architect of the Oxford vaccine, told me.

In the recriminations that followed, a plan emerged for how to tackle the next big one. At the end of a list of known threats was "Disease X" - the sinister name of a new, unknown infection that would take the world by surprise.

The Jenner Institute at the University of Oxford - named after the scientist that performed the first vaccination in 1796, and now home to some of the world's leading experts - designed a strategy for defeating an unknown enemy.

"We were planning how can we go really quickly to have a vaccine in someone in the shortest possible time," Prof Gilbert said.

"We hadn't got the plan finished, but we did do pretty well."

The central piece of their plan was a revolutionary style of vaccine known as "plug and play". It has two highly desirable traits for facing the unknown - it is both fast and flexible.

Conventional vaccines - including the whole of the childhood immunisation programme - use a killed or weakened form of the original infection, or inject fragments of it into the body. But these are slow to develop.

Instead the Oxford researchers constructed ChAdOx1 - or Chimpanzee Adenovirus Oxford One.

Scientists took a common cold virus that infected chimpanzees and engineered it to become the building block of a vaccine against almost anything.

Before Covid, 330 people had been given ChAdOx1 based-vaccines for diseases ranging from flu to Zika virus, and prostate cancer to the tropical disease chikungunya.

The virus from chimps is genetically modified so it cannot cause an infection in people. It can then be modified again to contain the genetic blueprints for whatever you want to train the immune system to attack. This target is known is an antigen.

ChAdOx1 is in essence a sophisticated, microscopic postman. All the scientists have to do is change the package.

"We drop it in and off we go," said Prof Gilbert.


It sounds strange to say it, almost perverse, but it was lucky that the pandemic was caused by a coronavirus.

This family of viruses had tried to jump from animals to people twice before in the past 20 years - Sars coronavirus in 2002 and Mers coronavirus in 2012.

It meant scientists knew the virus's biology, how it behaved and its Achilles heel - the "spike protein".

"We had a huge head start," Prof Andrew Pollard from the Oxford team said.


https://www.bbc.co.uk/news/health-55041371

 

I wonder if this science is the basis of the other vaccines too...?

 

So City has a big catchment are for fans?

 

Yep, and the city boundary needs to expand.

 

Anyone else think that being unable to see in-laws over the Christmas period is not necessarily a bad thing?